Formålet med dette kontrollerede interventionsstudie er at bestemme effekten af parodontalbehandling under graviditeten på ændringer i den metaboliske, inflammatoriske og hormonelle biomarkørprofil samt bestemme risikoen for udvikling af gestationel diabetes, præeklampsi, præterm fødsel og lav fødselsvægt.
![](data:image/svg+xml,<svg display="block" role="presentation" viewBox="0 0 503 64" xmlns="http://www.w3.org/2000/svg"><path d="M 56.571 41.754 C 56.038 42.486 55.04 43.151 54.042 43.151 C 52.111 43.151 50.712 41.663 50.712 37.872 C 50.712 33.949 52.31 31.529 55.04 31.529 C 55.623 31.527 56.204 31.594 56.771 31.729 Z M 31.358 4.39 L 43.853 26.998 L 43.987 26.998 L 51.711 16.72 C 52.073 16.236 52.178 16.053 53.243 16.053 C 55.906 16.053 56.904 18.78 56.904 23.037 L 56.904 23.437 L 56.771 30.688 C 55.108 29.491 52.776 29.025 49.58 29.025 C 44.054 29.025 38.195 32.551 38.195 39.27 C 38.195 45.656 42.456 48.981 47.45 48.981 C 51.845 48.981 55.24 46.452 56.638 42.861 C 57.038 46.652 60.7 48.981 64.894 48.981 C 68.49 48.981 70.952 47.584 72.284 45.322 C 72.75 44.458 72.95 43.459 72.817 42.661 L 72.684 42.661 C 72.284 43.259 71.751 43.527 71.087 43.527 C 70.021 43.527 69.422 42.463 69.555 39.935 L 70.088 29.889 C 70.088 29.69 70.154 28.958 70.154 28.094 C 70.154 23.237 68.889 20.045 66.625 17.984 C 64.028 15.587 60.033 14.723 55.24 14.723 C 51.29 14.723 45.347 16.156 41.013 17.927 L 41.013 1.686 L 0 1.686 L 0 21.243 L 0.133 21.243 L 9.654 4.39 C 10.12 3.525 10.386 3.393 11.452 3.393 L 13.358 3.393 L 13.358 41.064 C 13.358 42.195 13.292 42.328 12.759 42.995 L 8.497 48.316 L 8.497 48.448 L 32.514 48.448 L 32.514 48.316 L 28.254 42.995 C 27.721 42.328 27.654 42.195 27.654 41.064 L 27.654 3.393 L 29.561 3.393 C 30.626 3.393 30.893 3.525 31.358 4.39 Z M 112.952 45.055 L 115.549 48.316 L 115.549 48.448 L 95.841 48.448 L 95.841 48.316 L 98.372 45.055 C 98.838 44.458 98.904 44.258 98.904 43.393 C 98.904 42.063 99.103 33.749 99.103 30.291 C 99.103 25.434 98.57 21.108 94.377 21.108 C 92.646 21.108 91.58 21.841 90.581 22.971 L 90.581 43.393 C 90.581 44.258 90.648 44.458 91.114 45.055 L 93.711 48.316 L 93.711 48.448 L 74.069 48.448 L 74.069 48.316 L 76.6 45.055 C 77.066 44.458 77.133 44.258 77.133 43.393 L 77.133 20.376 C 77.133 19.513 77.066 19.312 76.6 18.714 L 74.069 15.389 L 74.069 15.255 L 90.581 15.255 L 90.581 21.664 C 92.246 17.607 95.776 14.723 101.567 14.723 C 108.758 14.723 112.62 19.978 112.62 29.158 C 112.62 33.749 112.487 38.138 112.42 43.393 C 112.42 44.258 112.487 44.458 112.952 45.055 Z M 140.833 41.354 L 140.833 20.353 C 140.301 20.021 139.1 19.247 137.836 19.247 C 134.707 19.247 131.312 21.907 131.312 31.686 C 131.312 40.401 133.774 42.995 137.304 42.995 C 138.636 42.995 139.967 42.219 140.833 41.354 Z M 154.281 43.393 C 154.281 44.258 154.348 44.458 154.814 45.055 L 157.411 48.316 L 157.411 48.448 L 140.833 48.448 L 140.833 42.529 C 138.768 46.786 135.439 48.981 130.979 48.981 C 123.055 48.981 117.13 43.459 117.13 31.821 C 117.13 21.709 123.256 14.723 132.244 14.723 C 136.239 14.723 139.235 16.188 140.833 19.312 L 140.833 7.427 C 140.833 6.56 140.765 6.363 140.301 5.762 L 137.769 2.438 L 137.769 2.303 L 154.281 0.309 Z M 175.261 43.393 C 175.261 44.258 175.327 44.458 175.793 45.055 L 178.391 48.316 L 178.391 48.448 L 158.749 48.448 L 158.749 48.316 L 161.279 45.055 C 161.745 44.458 161.811 44.258 161.811 43.393 L 161.811 7.427 C 161.811 6.56 161.745 6.363 161.279 5.762 L 158.749 2.438 L 158.749 2.303 L 175.261 0.309 Z M 211.973 29.514 L 219.496 29.514 C 219.896 17.274 217.965 16.053 215.901 16.053 C 213.371 16.053 212.039 18.007 211.973 29.514 Z M 199.966 40.407 C 198.635 38.078 198.124 35.934 198.124 32.609 L 198.124 31.61 C 197.591 31.412 196.926 31.22 196.326 31.22 C 193.597 31.22 191.998 33.949 191.998 37.872 C 191.998 41.663 193.93 43.593 196.06 43.593 C 197.591 43.593 199.084 42.361 199.966 40.407 Z M 198.057 30.438 C 198.057 29.573 198.191 24.701 198.191 23.037 C 198.191 18.848 197.193 16.428 194.53 16.428 C 193.464 16.428 193.397 16.497 192.997 17.16 L 186.23 27.306 L 186.097 27.306 L 181.303 17.33 C 186.164 15.599 191.333 14.723 195.861 14.723 C 199.988 14.723 202.651 15.587 205.248 17.984 C 205.448 18.182 205.647 18.315 205.781 18.515 C 208.311 16.119 211.574 14.723 216.167 14.723 C 223.559 14.723 231.814 17.783 231.814 29.69 C 231.814 30.155 231.814 30.488 231.747 31.088 L 211.973 31.088 C 212.173 38.87 216.567 41.464 221.427 41.464 C 225.022 41.464 229.15 39.869 231.215 36.341 L 231.347 36.409 C 229.483 45.055 223.957 48.981 215.7 48.981 C 209.642 48.981 203.783 46.452 200.588 41.53 C 199.988 44.458 196.726 48.981 189.668 48.981 C 184.008 48.981 179.481 45.656 179.481 39.27 C 179.481 32.551 185.34 29.025 190.867 29.025 C 194.062 29.025 196.259 29.438 198.057 30.438 Z M 250.331 35.168 C 252.461 35.168 253.727 33.548 253.727 25.631 C 253.727 17.85 252.527 16.23 250.331 16.23 C 248.134 16.23 246.935 17.85 246.935 25.566 C 246.935 33.615 248.267 35.168 250.331 35.168 Z M 243.14 52.838 C 241.942 53.703 241.21 54.634 241.21 56.164 C 241.21 60.09 246.069 62.307 251.396 62.307 C 256.057 62.307 261.05 60.687 261.05 56.831 C 261.05 54.702 260.051 53.637 255.723 53.504 L 246.069 53.172 C 245.004 53.106 244.072 53.038 243.14 52.838 Z M 250.265 14.723 C 254.992 14.723 258.453 15.656 260.185 16.454 C 260.783 16.72 260.984 16.651 261.716 15.988 L 268.908 9.47 L 269.04 9.536 L 269.04 19.447 L 262.715 19.447 C 264.778 21.177 265.911 23.171 265.911 26.364 C 265.911 33.949 259.586 36.675 250.464 36.675 C 248.201 36.675 246.069 36.542 244.14 36.143 C 243.54 36.542 243.14 37.142 243.14 37.872 C 243.14 39.734 245.604 40.667 250.464 40.667 L 257.122 40.667 C 264.845 40.667 269.04 43.259 269.04 49.313 C 269.04 57.827 260.652 64.146 248.6 64.146 C 242.009 64.146 234.884 62.284 234.884 58.093 C 234.884 55.766 236.882 53.438 242.475 52.706 C 237.281 51.641 234.351 48.649 234.351 44.789 C 234.351 40.466 237.88 37.34 243.407 36.009 C 238.281 34.745 234.751 31.753 234.751 25.832 C 234.751 17.916 241.075 14.723 250.265 14.723 Z M 283.694 29.514 L 291.216 29.514 C 291.282 28.449 291.282 27.694 291.282 26.762 C 291.282 17.317 289.486 16.053 287.622 16.053 C 285.091 16.053 283.694 18.139 283.694 29.514 Z M 283.694 31.088 C 283.959 38.87 288.287 41.464 293.148 41.464 C 296.743 41.464 300.87 39.869 302.934 36.341 L 303.069 36.409 C 301.204 45.055 295.612 48.981 287.357 48.981 C 278.367 48.981 269.713 43.86 269.713 32.018 C 269.713 19.912 277.634 14.723 287.888 14.723 C 295.279 14.723 303.534 17.783 303.534 29.69 C 303.534 30.155 303.534 30.488 303.467 31.088 Z M 320.917 22.971 L 320.917 44.746 C 321.649 45.213 322.514 45.853 323.646 45.853 C 327.042 45.853 330.438 44.125 330.438 31.821 C 330.438 23.437 328.041 21.108 324.711 21.108 C 323.182 21.108 321.916 21.775 320.917 22.971 Z M 320.917 21.598 C 323.529 16.428 326.294 14.723 331.57 14.723 C 339.56 14.723 344.619 21.441 344.619 31.821 C 344.619 42.195 337.895 48.981 328.64 48.981 C 325.177 48.981 322.514 48.182 320.519 45.853 L 307.601 48.981 L 307.469 48.981 L 307.469 7.427 C 307.469 6.56 307.403 6.363 306.936 5.762 L 304.405 2.438 L 304.405 2.303 L 320.917 0 Z M 362.337 43.393 C 362.337 44.258 362.403 44.458 362.87 45.055 L 365.467 48.316 L 365.467 48.448 L 345.825 48.448 L 345.825 48.316 L 348.356 45.055 C 348.821 44.458 348.889 44.258 348.889 43.393 L 348.889 7.427 C 348.889 6.56 348.821 6.363 348.356 5.762 L 345.825 2.438 L 345.825 2.303 L 362.337 0.309 Z M 379.074 37.872 C 379.074 41.663 380.474 43.459 382.404 43.459 C 383.402 43.459 384.401 42.486 384.933 41.754 L 385.134 31.544 C 384.601 31.412 384.003 31.22 383.402 31.22 C 380.673 31.22 379.074 33.949 379.074 37.872 Z M 385.268 23.437 L 385.268 23.037 C 385.268 18.78 384.268 16.362 381.605 16.362 C 380.54 16.362 380.406 16.428 380.074 17.029 L 373.307 27.306 L 373.172 27.306 L 368.379 17.33 C 373.239 15.599 379.074 14.723 383.602 14.723 C 388.396 14.723 392.39 15.587 394.988 17.984 C 397.251 20.045 398.516 23.237 398.516 28.094 C 398.516 28.958 398.45 29.69 398.45 29.889 L 397.916 39.935 C 397.783 42.463 398.384 43.527 399.45 43.527 C 400.113 43.527 400.646 43.259 401.047 42.661 L 401.179 42.661 C 401.313 43.459 401.113 44.458 400.646 45.322 C 399.314 47.584 396.853 48.981 393.258 48.981 C 389.062 48.981 385.4 46.652 384.999 42.861 C 383.602 46.452 380.206 48.981 375.813 48.981 C 370.819 48.981 366.557 45.656 366.557 39.27 C 366.557 32.551 372.417 29.025 377.943 29.025 C 381.14 29.025 383.47 29.306 385.134 30.504 Z M 426.618 41.354 L 426.618 20.353 C 426.085 20.021 424.888 19.247 423.622 19.247 C 420.493 19.247 417.099 21.907 417.099 31.686 C 417.099 40.401 419.562 42.995 423.09 42.995 C 424.421 42.995 425.753 42.219 426.618 41.354 Z M 440.068 43.393 C 440.068 44.258 440.134 44.458 440.602 45.055 L 443.199 48.316 L 443.199 48.448 L 426.618 48.448 L 426.618 42.529 C 424.556 46.786 421.226 48.981 416.764 48.981 C 408.84 48.981 402.916 43.459 402.916 31.821 C 402.916 21.709 409.041 14.723 418.029 14.723 C 422.024 14.723 425.02 16.188 426.618 19.312 L 426.618 7.427 C 426.618 6.56 426.552 6.363 426.085 5.762 L 423.556 2.438 L 423.556 2.303 L 440.068 0.309 Z M 458.008 29.514 L 465.532 29.514 C 465.599 28.449 465.599 27.694 465.599 26.762 C 465.599 17.317 463.8 16.053 461.937 16.053 C 459.406 16.053 458.008 18.139 458.008 29.514 Z M 458.008 31.088 C 458.276 38.87 462.603 41.464 467.463 41.464 C 471.059 41.464 475.186 39.869 477.25 36.341 L 477.383 36.409 C 475.519 45.055 469.925 48.981 461.67 48.981 C 452.682 48.981 444.026 43.86 444.026 32.018 C 444.026 19.912 451.95 14.723 462.202 14.723 C 469.594 14.723 477.849 17.783 477.849 29.69 C 477.849 30.155 477.849 30.488 477.783 31.088 Z M 481.983 38.936 L 481.983 16.96 L 478.919 16.96 L 478.919 15.255 L 481.582 15.255 C 482.647 15.255 483.114 15.255 483.847 14.591 L 495.298 3.814 L 495.431 3.814 L 495.431 15.255 L 502.888 15.255 L 502.888 16.96 L 495.431 16.96 L 495.431 38.138 C 495.431 41.13 496.762 42.795 498.761 42.795 C 500.159 42.795 501.224 42.129 501.957 41.199 L 502.089 41.264 C 501.424 44.923 498.495 48.981 491.504 48.981 C 485.113 48.981 481.983 45.456 481.983 38.936 Z" fill="rgb(35, 31, 32)" height="64.14577562426842px" id="tI0NzriIe" width="502.88759099942px"/></svg>)
