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I artiklen gives en oversigt over osteonekrosernes epidemiologi, symptomer, diagnostik, klinik og behandling. Endelig gives retningslinjer for, hvordan man skal forholde sig vedrørende tandbehandling, oral kirurgi og henvisning af patienter i antiresorptiv behandling.
Oversigtsartikel
DATO:
Dansk
English
Osteonekrose i kæberne (Eng. “osteonecrosis of the jaws”, forkortet ONJ) ses i stigende grad verden over. ONJ er en alvorlig komplikation til antiresorptiv behandling med bisfosfonat, denosumab samt visse kemoterapeutika. ONJ kan medføre tab af tænder og kæbedele og invalidere tyggefunktionen. Den antiresorptive behandling anvendes mod knoglemetastaser fra en række maligne tilstande samt mod osteoporose. I den senere tid anvendes antiresorptiv behandling også som adjudant behandling hos postmenopausale kvinder med brystcancer for at reducere risiko for tilbagefald af sygdommen. I artiklen gives en oversigt over osteonekrosernes epidemiologi, symptomer, diagnostik, klinik og behandling. Endelig gives retningslinjer for, hvordan man skal forholde sig vedrørende tandbehandling, oral kirurgi og henvisning af patienter i antiresorptiv behandling.
forfattere
Morten Schiødt
overtandlæge, specialtandlæge, dr.odont., Tand- Mund-Kæbekirurgisk Klinik, Rigshospitalet
Cecilia Larson Wexell
associate professor, ph.d., senior consultant OMFS, Department of Oral and Maxillofacial Surgery, Skåne University Hospital, Lund; Department of Oral and Maxillofacial Surgery and Oral Medicine, Faculty of Odontology, Malmö University, and Department of Biomaterials, Sahlgrenska Academy, University of Gothenburg, Sweden
Bente Brokstad Herlofson
professor, ph.d., Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway, and Unit of Oral and Maxillofacial Surgery, Department of Otorhinolaryngology – Head, neck and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway
Camilla Ottesen
forskningsårsstuderende, stud.odont., Tand-Mund- Kæbe-kirurgisk Klinik, Rigshospitalet
Sven Erik Nørholt
klinisk professor, overtandlæge, ph.d. Afdeling for Tand-, Mund- og Kæbekirurgi, Aarhus Universitetshospital
