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Antibiotics in the treatment of periodontal and peri-implant infections

ABSTRACT

Oversigtsartikel Dato: 27.02.2019

Adjunctive use of systemic antibiotics in the treatment of periodontitis and peri-implant infections has for many years been in focus for investigators due to the diversity in clinical picture and variability in treatment response in these conditions. Antimicrobial resistance has emerged as a serious problem worldwide and is one of the most important threats to global health as a result of misuse/overuse of antibiotics. Considering the diversity of the microbiota in the oral cavity and its potential to be a reservoir for antibiotic resistance genes, the misuse of antibiotics can result in negative effects for the individual and its surroundings. With the questionable positive long-term effect of antibiotics in most periodontal infections, use of antibiotics should be restricted and only considered after microbiological diagnostic testing that includes species identification and antibiotic susceptibility testing. For peri-implant infections, there is scarce evidence for the use of systemic antibiotics with no proven effective treatment protocol for good results on a long-term basis.

Clinical relevance
Antimicrobial resistance has emerged as a serious problem worldwide and is one of the most important threats to global health as a result of antibiotic overuse. Considering the questionable positive and limited long-term effect in periodontal treatment, the adjunctive use of systemic antibiotics should be restricted to aggressive periodontitis and/or unresponsive cases of advanced periodontitis. Microbiological analysis including susceptibility testing are recommended in cases where antibiotics are considered as an adjunct to systematic periodontal treatment. Evidence on the use of systemic antimicrobials as an adjunct for peri-implantitis treatment is still scarce with no proven effective treatment protocol.